姓名：杨丽华

性别：女

政治面貌：中共党员

职称：教授

邮箱：yanglihua@mail.hzau.edu.cn

个人简介：

教授，博士生导师。主要聚焦新污染物的生态及健康风险研究，结合分子毒理和多组学技术解析其致毒机制与作用靶点；研发生物毒性监测预警技术，结合生物传感与智能算法，构建快速响应平台，推动毒理学发现向高灵敏监测工具转化，形成“机制→技术→应用”全链条体系，支撑环境风险防控。目前已发表学术论文80余篇，其中第一/通讯作者论文40余篇（含1篇EHP及10篇EST），总他引2000余次，H指数24，获授权发明专利1项、软著1项，出版专著/教材1部（排名第二），获湖北省“青年拔尖人才”称号。

教育背景：

2006.09~2011.06 中国科学院生态环境研究中心 环境科学  博士

2002.09~2006.06 四川大学 建筑与环境学院 环境科学专业 本科

工作经历：

2026.01~至今  华中农业大学  教授

2011.07 ~ 2025.12 中国科学院水生生物研究所  助理研究员、副研究员、青年研究员、研究员

                  其中2018.8~2019.8 美国佛罗里达大学    访问学者

主持科研项目：

1. 湖北省“青年拔尖”人才计划，2025.01~2027.12，在研，主持。

2. 国家自然科学基金面上项目，42377281，新溴代阻燃剂对斑马鱼肝脏发育和再生过程的影响及分子机制研究，2024.1~2027.12，在研，主持。

3. 国家自然科学基金面上项目，42177268，新型溴代阻燃剂对中枢神经系统的内暴露、毒性效应及分子机制研究，2022.1~2025.12，在研，主持。

4. 国家重点研发计划子课题，2022YFC3902102，基于多组学数据的有害结局路径（AOP）解析及预测，2021.11~2025.10，在研，主持。

5. 国家重点研发计划子任务，2021YFC3200100，流域候选特征污染物对敏感指示水生生物的毒性测试，2022.1~2025.11，在研，主持。

6. 企业委托，长湖水生态监测与修复效果评估，2023.1~2026.12，在研，主持。

7. 国家自然科学基金青年基金，21307153，斑马鱼多巴胺系统作为多溴联苯醚作用靶点的毒性效应和分子机制研究，2014.1~2017.12，结题，主持。

8. 水生所知识创新工程青年人才领域前沿项目，PBDEs对斑马鱼的神经发育毒性效应和分子机理，2012.1~2014.12，结题，主持。

9. 企业委托，源江河及八郎溪、白浪溪支流生态环境现状调查分析，2023.6~2026.6，结题，主持。

10.  企业委托，长江上游表层水体、底质中新污染物含量分析，2022.11~2023.6，结题，主持。

11. 企业委托，新型冠状病毒传播与环境的关系及风险防控，2020.12~2022.12，结题，主持。

12. 企业委托，丹江口库区地表水及底泥农药及抗生素含量分析项目，丹江口库区地表水及底泥农药及抗生素含量分析，2020.8~2021.12，结题，主持。

13. 高校委托，武汉市重点河流湖泊水体、土壤、沉积物中抗生素含量分析，2021.7 ~ 2023.6，结题，主持。

代表论著：

1. Yang Lihua#, Zhang Yindan#, Hua Jianghuan*, Song Guili, Li Fan, Zheng Na, Zhang Taotao, Xu Zhixiang, Ren Xinxin, Zhu Biran, Han Yanna, Guo Yongyong, Han Jian, Zhou Bingsheng*, Integrated Studies on Male Reproductive Toxicity of Decabromodiphenyl Ethane in Zebrafish Spermatozoa ex Vivo, Male Zebrafish in Vivo, and GC-1 Cells in Vitro, Environmental Health Perspectives, 2024, 132: 117005. (SCI, 共同第一作者; IF5y=10.4; JCR=2.6%)

2. Zheng Na, Wang Xiaochen, Zhang Yindan, Hua Jianghuan, Zhu Biran, Zhou Yuxi, Xu Zhixiang, Luo Lijun, Han Jian, Yang Lihua*, Zhou Bingsheng, Mechanistic Insights into 1,2-bis(2,4,6-tribromophenoxy)ethane-Induced Male Reproductive Toxicity in Zebrafish, Environmental Science & Technology, 2024, 58: 8251-8263. (SCI, 唯一通讯作者; IF5y=11.6; JCR=5%)

3. Fu Kaiyu, Zhu Biran, Sun Yumiao, Zhou Yuxi, Pang Hao, Ren Xinxin, Guo Yongyong, Shi Xiongjie, Han Jian, Yang Lihua*, Zhou Bingsheng: Bis(2-ethylhexyl)-tetrabromophthalate Poses a Higher Exposure Risk and Induces Gender-Specific Metabolic Disruptions in Zebrafish Liver. Environmental Science & Technology 2024, 4937-4947. (SCI, 唯一通讯作者; IF5y=11.6; JCR=5%)

4. Fu Kaiyu, Hua Jianghuan, Zhang Yindan, Du Mingpu, Han Jian, Li Na, Wang Qiangwei, Yang Lihua*, Li Ruiwen*, Zhou Bingsheng: Integrated Studies on Male Reproductive Toxicity of Bis(2-ethylhexyl)-tetrabromophthalate: in Silico, in Vitro, ex Vivo, and in Vivo. Environmental Science & Technology 2024, 58: 194-206. (SCI, 共同通讯作者; IF5y=11.6; JCR=5%)

5. Zhou Yuxi, Li Fan, Fu Kaiyu, Zhang Yindan, Zheng Na, Tang Huijia, Xu Zhixiang, Luo Lijun, Han Jian, Yang Lihua*, Zhou Bingsheng*: Bis(2-ethylhexyl)-2,3,4,5-tetrabromophthalate Enhances foxo1-Mediated Lipophagy to Remodel Lipid Metabolism in Zebrafish Liver. Environmental Science & Technology 2024, 58: 4581-4593. (SCI, 共同通讯作者; IF5y=11.6; JCR=5%)

6. Sun Yumiao, Wang Xiaochen, Guo Wei, Li Fan, Hua Jianghuan, Zhu Biran, Guo Yongyong, Han Jian, Yang Lihua* Zhou Bingsheng: Life-time exposure to decabromodiphenyl ethane (DBDPE) caused transgenerational epigenetic alterations of thyroid endocrine system in zebrafish. Science of the Total Environment 2024, 950: 175337. (SCI, 唯一通讯作者; IF5y=8.6; JCR=8.7%)

7. Zhou Yuxi, Lei Lei, Zhu Biran, Li Ruiwen, Zuo Yanxia, Guo Yongyong, Han Jian, Yang Lihua*, Zhou Bingsheng: Aggravated visual toxicity in zebrafish larvae upon co-exposure to titanium dioxide nanoparticles and bis(2-ethylhexyl)-2,3,4,5-tetrabromophthalate. The Science of the Total Environment 2024, 921: 171133. (SCI, 唯一通讯作者; IF5y=8.6; JCR=8.7%)

8. Li Ruiwen, Pang Hao, Guo Yemin, Zhou Xuan, Fu Kaiyu, Zhang Taotao, Han Jian, Yang Lihua*, Zhou Bingsheng, Zhou Si*: Distribution of Polycyclic Aromatic Hydrocarbons and Pesticides in Danjiangkou Reservoir and Evaluation of Ecological Risk. Toxics 2024, 12(12): 859. (SCI, 共同通讯作者; IF5y=4.2; JCR=21.6%)

9. Yang Lihua, Zhu Biran, Zhou Shanqi, Zhao Min, Li Ruiwen, Zhou Yuxi, Shi Xiongjie, Han Jian, Zhang Wei, Zhou Bingsheng: Mitochondrial Dysfunction Was Involved in Decabromodiphenyl Ethane-Induced Glucolipid Metabolism Disorders and Neurotoxicity in Zebrafish Larvae. Environmental Science & Technology 2023, 57, 11043-11055. (SCI, 唯一第一作者; IF5y=11.6; JCR=5%)

10. Sun Yumiao, Zhou Shanqi, Zhu Biran, Li Fan, Fu Kaiyu, Guo Yongyong, Men Jun, Han Jian, Zhang Wei, Yang Lihua*, Zhou Bingsheng, Multi- and Transgenerational Developmental Impairments Are Induced by Decabromodiphenyl Ethane (DBDPE) in Zebrafish Larvae. Environmental Science & Technology 2023, 57: 2887-2897. (SCI, 唯一通讯作者; IF5y=11.6; JCR=5%)

11. Li Fan, Song Guili, Wang Xiaochen, Sun Yumiao, Zhou Shanqi, Zhang Yindan, Hua Jianghaun, Zhu Biran, Yang Lihua*, Zhang Wei, Zhou Bingsheng: Evidence for Adverse Effects on Liver Development and Regeneration in Zebrafish by Decabromodiphenyl Ethane. Environmental Science & Technology 2023, 57, 19419-19429. (SCI, 唯一通讯作者; IF5y=11.6; JCR=5%)

12. Sun Yumiao, Wang Xiaochen, Zhou Shanqi, Zhou Yuxi, Hua Jianghuan, Guo Yongyong, Wang Yan, Zhang Wei, Yang Lihua*, Zhou Bingsheng*: Evaluation and Mechanistic Study of Transgenerational Neurotoxicity in Zebrafish upon Life Cycle Exposure to Decabromodiphenyl Ethane (DBDPE). Environmental Science & Technology 2023, 57, 16811-16822. (SCI, 共同通讯作者; IF5y=11.6; JCR=5%)

13. Zhu Biran, Lei Lei, Sun Yumiao, Shi Xiongjie, Fu Kaiyu, Hua Jianghuan, Martyniuk Christopher J., Han Jian*, Yang Lihua*, Zhou Bingsheng, Niclosamide Exposure at Environmentally Relevant Concentrations Efficaciously Inhibited the Growth and Disturbed the Liver-Gut Axis of Adult Male Zebrafish. Environmental Science & Technology 2022, 56: 11516-11526. (SCI, 共同通讯作者; IF5y=11.6; JCR=5%)

14. Sun Yumiao, Zhu Biran, Ling Siyuan, Yan Biao, Wang Xiulin, Jia Shuzhao, Martyniuk Christopher J., Zhang Wei, Yang Lihua*, Zhou Bingsheng*: Decabromodiphenyl Ethane Mainly Affected the Muscle Contraction and Reproductive Endocrine System in Female Adult Zebrafish. Environmental Science & Technology 2022, 56(1):470-479. (SCI, 共同通讯作者; IF5y=11.6; JCR=5%)

15. Hu Zhichao#, Yang Lihua#, Han Jian, Liu Zishu, Zhao Yuxiang, Jin Yihao, Sheng Yaqi, Zhu Lizhong, Hu, Baolan, Human viruses lurking in the environment activated by excessive use of COVID-19 prevention supplies. Environment International 2022, 163, 107192. (SCI, 共同第一作者; IF5y=11.1; JCR=5.9%)

16. Liu Sitian, Song Guili, Li Fan, Li Ruiwen, Chen Xiangping, Guo Yongyong, Zhou Fang, Wang Qiangwei, Yang Lihua*, Zhou Bingsheng, Bis (2-ethylhexyl)-2,3,4,5-tetrabromophthalate showed poor penetrability but increased the permeability of blood brain barrier: Evidences from in vitro and in vivo studies. Journal of Hazardous Materials 2022, 424: 127386. (SCI, 共同通讯作者; IF5y=11.9; JCR=3.4%)

17. Hua Jianghuan, Wang Xiulin, Zhu Jiaping, Wang Qiangwei, Zhang Wei, Lei Lei, Zhu Biran, Han Jian, Yang Lihua*, Zhou Bingsheng, Ecotoxicology and Environmental Safety 2022, 244: 114044. (SCI, 唯一通讯作者; IF5y=6.3; JCR=8.5%)

18. Wang Xiulin, Sun Yumiao, Fu Mengru, Chen Pengyu, Wang Qiangwei, Hua Jianghuan, Fu Kaiyu, Zhang Wei, Zhu Lifei, Yang Lihua*, Zhou Bingsheng. Nano-TiO2 Adsorbed Decabromodiphenyl Ethane and Changed Its Bioavailability, Biotransformation and Biotoxicity in Zebrafish Embryos/Larvae. Frontiers in Environmental Science 2022, 10, 860786. (SCI, 唯一通讯作者; IF5y=3.7; JCR=46.5%)

19. Yang Lihua, Ivantsova Emma, Souders Christopher L., Martyniuk Christopher J.: The agrochemical S-metolachlor disrupts molecular mediators and morphology of the swim bladder: Implications for locomotor activity in zebrafish (Danio rerio). Ecotoxicology and Environmental Safety 2021, 208: 111641. (SCI, 唯一第一作者; IF5y=6.3; JCR=8.5%)

20. Li Ruiwen, Yang Lihua*, Han Jian, Zou Yu, Wang Yingcai, Feng Chenglian, Zhou Bingsheng: Early-life exposure to tris (1,3-dichloro-2-propyl) phosphate caused multigenerational neurodevelopmental toxicity in zebrafish via altering maternal thyroid hormones transfer and epigenetic modifications. Environmental Pollution 2021, 285:117471. (SCI, 唯一通讯作者; IF5y=8.3; JCR=10.3%)

21. Chen Xiangping, Lei Lei, Liu Sitian, Han Jian, Li Ruiwen, Men Jun, Li Lin, Wei Lin, Sheng Yaqi, Yang Lihua*, Zhou Bingsheng, Zhu Lizhong: Occurrence and risk assessment of pharmaceuticals and personal care products (PPCPs) against COVID-19 in lakes and WWTP-river-estuary system in Wuhan, China. Science of The Total Environment 2021, 792: 148352. (SCI, 唯一通讯作者; IF5y=8.6; JCR=8.7%)

22. Yang Lihua, Zha Jinmiao*, Guo Yongyong, Zhou Bingsheng: Evaluation and mechanistic study of chlordecone-induced thyroid disruption: Based on in vivo, in vitro and in silico assays. Science of The Total Environment 2020, 716:136987. (SCI, 唯一第一作者; IF5y=8.6; JCR=8.7%)

23. Yang Lihua, Huang Tao, Li Ruiwen, Souders Christopher, Rheingold Spencer, Tischuk Claire, Li Na, Zhou Bingsheng, Martyniuk Christopher J. *: Evaluation and comparison of the mitochondrial and developmental toxicity of three strobilurins in zebrafish embryo/larvae. Environmental Pollution 2020:116277. (SCI, 唯一通讯作者; IF5y=8.3; JCR=10.3%)

24. Peng Wei, Liu Sitian, Guo Yongyong, Yang Lihua*, Zhou Bingsheng: Embryonic exposure to pentabromobenzene inhibited the inflation of posterior swim bladder in zebrafish larvae. Environmental Pollution 2020, 259:113923. (SCI, 唯一通讯作者; IF5y=8.3; JCR=10.3%)

主要兼职：

1. 编委，Ecotoxicology and Environmental Safety，JCR一区；

2. 编委，Neurotoxicology and Teratology， JCR二区；

3. 青年编委，Hygiene and Environmental Health Advances，高起点新刊；

4. 编委，生态毒理学报，中文核心期刊。